Signal Transduction Reagents and Kits
Medchemexpress LLC MC-Val-Cit-PAB-vinblastine | 2055896-92-7 | 99.5% | 1366.62 | C74H97N10O15 | 10 MG
MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for antibody-drug conjugate (ADC) research that links the microtubule inhibitor vinblastine to a cleavable val-cit-PAB-type linker. It is supplied as a white to light brown solid (CAS 2055896-92-7), with molecular formula C74H97N10O15 and molecular weight 1366.62 g/mol. Intended for research and analytical applications; not for human therapeutic use.
- Drug-linker conjugate designed for ADC research
- Vinblastine payload with microtubule inhibitory activity
- Cleavable linker for lysosomal release
- High purity suitable for analytical applications
- Solid form, white to light brown appearance
- Storage recommendations: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month)
- Available as a 10 mg pack
Revvity Health Sciences Inc Terbium SureFire Ultra Human Phospho-STAT3 (Tyr705 ) Detection Kit, 10,000 Assay Points
Terbium SureFire Ultra Human Phospho-STAT3 (Tyr705 ) Detection Kit, 10,000 Assay Points
Enzo Life Sciences SB-202190 (1mg). CAS: 152121-30-7
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis. Alternative name: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Purity: ≥98% (TLC). Solubility: Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. Long Term Storage: -20°C.
![Medchemexpress LLC 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione | 522649-59-8 | 99.7% | 351.4 g/mol | C20H21N3O3 | 25MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000235713.png-250.jpg)
Medchemexpress LLC 3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione | 522649-59-8 | 99.7% | 351.4 g/mol | C20H21N3O3 | 25MG
Malic enzyme inhibitor ME1 is a small-molecule probe that selectively inhibits the cytosolic NADP+-dependent malic enzyme 1 (ME1) with an in vitro IC50 of 0.15 μM. Supplied as a high-purity solid, it is intended for use in biochemical and cell-based studies to interrogate ME1-dependent metabolic pathways and related cellular phenotypes.
- Potent ME1 inhibition (IC50 0.15 μM).
- High purity (≈99.7%).
- Available in multiple vial sizes for scalability.
- Suitable for biochemical and cell-based assays.
- Supports mechanistic studies of metabolism and disease.
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan >=98% (HPLC) | 139264-17-8 | MFCD00871503 | 50MG
Zolmitriptan >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 287.36 | 139264-17-8 | MFCD00871503 | 50MG
CPC Scientific Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt) 1MG
Nonapeptide capable of inhibiting the conversion of angiotensin I to angiotensin II, in vitro and in vivo. Bradykinin Potentiator.SEQUENCE: Glp-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: Glp-WPRPQIPPMOLECULAR FORMULA: C53H76N14O12MOLECULAR WEIGHT: 1101.3STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [35115-60-7]SYNONYMS: RESEARCH AREA: CardiovascularREFERENCES:M.A. Ondetti et al., Biochemistry, 10, 4033 (1971)H.S. Cheung and D.W. Cushman, Biochim. Biophys. Acta, 293, 451 (1973)L.C. Martin et al., Biochem. J., 184, 713 (1979)D.I. Marlborough et al., Arch. Biochem. Biophys., 210, 43 (1981)SKU(s): ACEI-001A, ACEI-001B, ACEI-001C
Echelon Biosciences Research Labs GLO-PI(3,4,5)P3BODIPYTMR100ug
BODIPY TMR PI(3,4,5)P3 (BODIPY TMR Phosphatidylinositol 3,4,5-trisphosphate) is a water soluble analog of PI(3,4,5)P3 (PIP3) labeled with the orange fluorophore, Bodipy-TMR, at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. This item is non returnable
Echelon Biosciences Research Labs APP Gamma Secretase Inhibitor - 5 mg, CAS#: 208255-80-5
APP Gamma Secretase Inhibitor - 5mg , N-[N-(3,5-Difluorophenacetyl)-Ala]-S-phenylglycine t-butyl ester Category/Application: Enzyme Substrates This item is non returnable
Echelon Biosciences Research Labs PI(5)P PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 500 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Neogen Diagnostics K-Blue Luminescent Substrate, 500 ML, HRP, Microwell, Chemiluminescent
K-Blue Luminescent is a stabilized luminescent substrate for use with horseradish peroxidase immunoassays. It contains both luminol and hydrogen peroxide (H2O2) in a two-bottle format with long-term stability, high sensitivity, and excellent signal to noise. Maximal light emission occurs at 430 nm in the presence of peroxidase labeled conjugate. K-Blue Luminescent is compliant with Annex XVII for REACH and contains no hazardous substances at or above published reporting levels. Stable for a minimum of 18-months when stored at 2-8C.
Enzo Life Sciences Sulindac sulfide (5mg). CAS: 32004-67-4
Active metabolite of sulindac (ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling. Alternative name: Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid. Purity: ≥99% (TLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml, warm). Long Term Storage: Ambient.
Carnabio Usa Inc MRCKA(CDC42BPA)/5UG/TRUNCATED
MRCK(CDC42BPA), Truncated protein, Wild type, Amino Acid 1-574, NP_003598.2, Expressed in Insect (sf21); 5microg
Carnabio Usa Inc MRCKA(CDC42BPA)/10UG/TRUNCATED
MRCK(CDC42BPA), Truncated protein, Wild type, Amino Acid 1-574, NP_003598.2, Expressed in Insect (sf21); 10microg
Enzo Life Sciences Ac-Leu-Leu-Nle-al (5 mg) CAS: 110044-82-1
Cysteine protease inhibitor. Alternative Name: ALLN, Calpain inhibitor I, Ac-LL-norleucinal. Formula: C20H37N3O4. MW: 383.5. CAS: 110044-82-1. Purity: ≥95% (HPLC). Sequence N-Acetyl-Leu-Leu-Nle-CHO. Appearance: White powder. Solubility: Soluble in ethanol (5 mg/ml) or DMSO (10 mg/ml). Long Term Storage: -20°C. Handling: Store dry and protect from light.